||Strong evidence from at least one systematic review of multiple well-designed, randomized controlled trials.
||Strong evidence from at least one properly designed, randomized controlled trial of appropriate size.
||Evidence from well-designed trials without randomization, single group pre-post, cohort, time series, or matched case-control studies.
||Evidence from well-designed, non-experimental studies from more than one center or research group.
||Opinions of respected authorities, based on clinical evidence, descriptive studies, or reports of expert committees.